My major research interest is focused upon biochemical, immunological, and molecular unraveling of a unique alphaherpesvirus which is naturally found in the macaque monkey host, B virus. This unique, deadly agent is the causative agent of one of the most feared occupational hazards in biomedical science involving macaque monkeys, their cells, tissues, and mucosal fluids. Although the virus is nearly identical to HSV-1 and HSV-2, commonly found in the human population, it is capable of causing death of the human host in as little as weeks following onset of acute disease. We have discovered that morbidity can be reduced in conjunction with early identification of infection followed by initiation of acyclovir therapy. The often fatal outcome of B virus zoonotic infection has spurred investigators to understand the molecular aspects of the virus, the natural host and the foreign host properties that, together, mitigate infection and disease.

Understanding this agent, its capabilities, the pathogenesis of infection in both the natural host and the foreign host in the depth required to control and subsequently prevent future loss of life and minimize severe disease, if not eradicate this threat completely is the goal of the work I do. Understanding more completely the viruses which are associated with a species enables scientists and clinicians to be more readily prepared to identify and control infections and diseases which may emerge in the population in the near as well as long term future.

Systematic sequence analysis of the genes of herpes B virus coupled with transcription mapping of this virus are the immediate hot projects. The hottest projects which will be forthcoming from these endeavors include both enhanced diagnostics and vaccine design.

The state of Georgia is energetically pursuing a strategic course towards leadership in education and research. This vital energy is apparent through the influence of the Georgia Research Alliance and its close ties to state and national leadership, which in turn have a tremendous impact on funding basic research and improving resources for higher education. Georgia is an exciting place to be and Atlanta provides an enriched environment for basic science investigation. Resources are provided at a level to enable growth and development of investigational programs, future enterprise, and global collaborations.